BDBM484243 (S)-1-(2-(1-(4-(3-chloro-2- fluorophenoxy)phenyl)-8- methylimidazo[1,5-a]pyrazin-3- yl)piperidin-1-yl)prop-2-en-1-one::US10933063, Compound 42::US11554118, Compound 42

SMILES Cc1nccn2c(nc(-c3ccc(Oc4cccc(Cl)c4F)cc3)c12)[C@@H]1CCCCN1C(=O)C=C

InChI Key InChIKey=NKODSCHFCMUWEZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484243   

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484243(US10933063, Compound 42 | (S)-1-(2-(1-(4-(3-chloro...)
Affinity DataIC50: 55nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484243(US10933063, Compound 42 | (S)-1-(2-(1-(4-(3-chloro...)
Affinity DataIC50: 55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent