BDBM484440 US10934285, Example 24::US12053470, Compound 47

SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1

InChI Key InChIKey=QZVSNMBRLYUYQI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 484440   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484440(US10934285, Example 24 | US12053470, Compound 47)
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM484440(US10934285, Example 24 | US12053470, Compound 47)
Affinity DataIC50: 1nMAssay Description:Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM484440(US10934285, Example 24 | US12053470, Compound 47)
Affinity DataIC50: 1nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent