BDBM484651 (E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan-2- yl)imidazo[1,5- a]pyrazin-1-yl)-N- (pyridin-2- yl)benzamide::US10934296, Example 97

SMILES COC\C=C\C(=O)N1CCCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

InChI Key InChIKey=OEXJPOPQZBWMNU-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 484651   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484651(US10934296, Example 97 | (E)-4-(8-amino-3-(1- (4-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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TargetTyrosine-protein kinase Fyn(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484651(US10934296, Example 97 | (E)-4-(8-amino-3-(1- (4-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484651(US10934296, Example 97 | (E)-4-(8-amino-3-(1- (4-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484651(US10934296, Example 97 | (E)-4-(8-amino-3-(1- (4-m...)
Affinity DataEC50:  55nMAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484651(US10934296, Example 97 | (E)-4-(8-amino-3-(1- (4-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent