BDBM486232 N-[4-(2,4-difluorophenoxy)-3-(5-methoxy-1- methyl-6-oxopyridin-3-yl) phenyl]methanesulfonamide::US10941160, Example 442

SMILES COc1cc(cn(C)c1=O)-c1cc(NS(C)=O)ccc1Oc1ccc(F)cc1F

InChI Key InChIKey=WPNFOEPUJOFFRT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486232   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM486232(N-[4-(2,4-difluorophenoxy)-3-(5-methoxy-1- methyl-...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent