BDBM488315 US10954240, Example 17

SMILES COc1ccncc1-c1ccc2cnn(-c3ccnc(c3)N3CCOCC3)c2c1

InChI Key InChIKey=JBEFOEVPCXACOV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488315   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527,G2019S](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM488315(US10954240, Example 17)Copy SMILESCopy InChI

Affinity DataIC50: 43nMAssay Description:LRRK2 Km ATP LanthaScreen Assaya) 400 nl of a 1:2.15 serial dilution of test compound (98 μM top assay concentration) is spotted via Labcyte Ech...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM488315(US10954240, Example 17)Copy SMILESCopy InChI

Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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