BDBM488367 2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin-5-yl)-3-chloro-N-methyl-1H-indole-6- carboxamide::US10954241, Example 7::US11548896, Example 7

SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1cn(C(C)C)c2ncnc(N)c12

InChI Key InChIKey=ZWNXAOSIOZQDJI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488367   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 8.03nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 1.57E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 13nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 8.03nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 1.57E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 13nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent