BDBM488479 1-(5-chloro-3- (2,3- dichlorophenyl)- 1H-pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin- 4-amine::US10954243, Example 10

SMILES CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1Cl

InChI Key InChIKey=GMMYNGZNVPRARM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 488479   

LigandPNGBDBM488479(1-(5-chloro-3- (2,3- dichlorophenyl)- 1H-pyrazolo[...)
Affinity DataIC50: 277nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent