BDBM488490 (6-((3S,4S)-4- amino-3-methyl- 2-oxa-8- azaspiro[4.5]decan- 8-yl)-3-(2- chloro-3-(oxetan- 3-yloxy)phenyl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl)methanol::US10954243, Example 21

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cccc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N

InChI Key InChIKey=OEDYNTUWDQTXOH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 488490   

LigandPNGBDBM488490((6-((3S,4S)-4- amino-3-methyl- 2-oxa-8- azaspiro[4...)
Affinity DataIC50: 558nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent