BDBM489128 2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(3- fluorophenoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; ;::US10961200, Compound 509::US11247971, Cmpd ID 509

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(Oc3cccc(F)c3)c2)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=UACMDFRHXGCQKU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 489128   

TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489128(US10961200, Compound 509 | 2-(5- (cyclopropylmethy...)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489128(US10961200, Compound 509 | 2-(5- (cyclopropylmethy...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489128(US10961200, Compound 509 | 2-(5- (cyclopropylmethy...)
Affinity DataIC50: 970nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed