BDBM489401 US10961247, Ex. No. 16

SMILES FC(F)n1cc(Nc2nc(N[C@@H]3CCCN(C3)C(=O)C=C)c3cc[nH]c3n2)cn1

InChI Key InChIKey=NDWBUHNJHOUAIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489401   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489401(US10961247, Ex. No. 16)
Affinity DataIC50: 0.400nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489401(US10961247, Ex. No. 16)
Affinity DataIC50: 10.1nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent