BDBM489425 US10961247, Ex. No. 40

SMILES Clc1c[nH]c2nc(Nc3cnn(CCN4CCOCC4)c3)nc(N[C@@H]3CCCN(C3)C(=O)C=C)c12

InChI Key InChIKey=RRIJEQWBYCPYKV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489425   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489425(US10961247, Ex. No. 40)
Affinity DataIC50: 0.200nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489425(US10961247, Ex. No. 40)
Affinity DataIC50: 1.80nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent