BDBM489445 US10961247, Ex. No. 58

SMILES COc1cccc(Cn2cc(Nc3nc(N[C@@H]4CCCN(C4)C(=O)C=C)c4c(Cl)n[nH]c4n3)cn2)c1

InChI Key InChIKey=RGEDADHWCUYEEQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489445   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489445(US10961247, Ex. No. 58)
Affinity DataIC50: 0.5nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489445(US10961247, Ex. No. 58)
Affinity DataIC50: 1.80nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent