BDBM490211 4-((1S,2R)-2-(cyclo- butylamino)cyclo- propyl)-N-(1-methyl- 1H-pyrazol-4- yl)thiophene-2- carboxamide::US10968213, Example 89

SMILES Cn1cc(NC(=O)c2cc(cs2)C2C[C@H]2NC2CCC2)cn1

InChI Key InChIKey=RIILCHKMPVLDAX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 490211   

TargetLysine-specific histone demethylase 1A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM490211(US10968213, Example 89 | 4-((1S,2R)-2-(cyclo- buty...)
Affinity DataIC50: 100nMAssay Description:LSD1: A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM490211(US10968213, Example 89 | 4-((1S,2R)-2-(cyclo- buty...)
Affinity DataIC50: 1.00E+5nMAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM490211(US10968213, Example 89 | 4-((1S,2R)-2-(cyclo- buty...)
Affinity DataIC50: 1.00E+5nMAssay Description:The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent