BDBM490720 US10968236, Compound I-48

SMILES CN1C(=O)C(C)(c2ccccc12)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1

InChI Key InChIKey=ADUNXSICBTXKDV-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 490720   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM490720(US10968236, Compound I-48)
Affinity DataKi: <10nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM490720(US10968236, Compound I-48)
Affinity DataKi:  55nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM490720(US10968236, Compound I-48)
Affinity DataKi:  55nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM490720(US10968236, Compound I-48)
Affinity DataKi:  550nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent