BDBM490847 5-[[5-(2-methoxy-4-piperazin-1-yl- phenyl)-1H-pyrazol-3- yl]amino]pyrazine-2-carbonitrile hydrochloride::US10973817, Example 46

SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCNCC1

InChI Key InChIKey=QGAWZWHMEVGIFJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490847   

TargetSerine/threonine-protein kinase Chk1(Human)
Sentinel Oncology

US Patent
LigandPNGBDBM490847(US10973817, Example 46 | 5-[[5-(2-methoxy-4-pipera...)
Affinity DataIC50: 0.0540nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required cofactors...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2021
Entry Details
US Patent