BDBM491112 2-((3,5-Dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl)thio)-2-phenylacetamide::US10975056, Example 254::US10975056, Example 255::US10975056, Example 56

SMILES CCc1c(C#N)c(SC(C(N)=O)c2ccccc2)nc(N2CCCN(C)CC2)c1C#N

InChI Key InChIKey=RKAYIEFADPAEOO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 491112   

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491112(US10975056, Example 56 | US10975056, Example 255 |...)
Affinity DataIC50: 320nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491112(US10975056, Example 56 | US10975056, Example 255 |...)
Affinity DataIC50: 320nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491112(US10975056, Example 56 | US10975056, Example 255 |...)
Affinity DataIC50: 1.65E+4nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent