BDBM492339 US10975080, Example 37

SMILES Cn1c(nc2[nH]nc(-c3ccnc(N)c3Cl)c2c1=O)N1CCC2(C[C@H](F)C[C@H]2N)CC1

InChI Key InChIKey=DYEPJMMWFQKKPN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492339   

LigandPNGBDBM492339(US10975080, Example 37)
Affinity DataIC50: 27nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent