BDBM492344 US10975080, Example 42

SMILES COc1ccc(cc1)-c1n[nH]c2nc(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)n(C)c(=O)c12

InChI Key InChIKey=DQFDNCXWZUGLAI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492344   

LigandPNGBDBM492344(US10975080, Example 42)
Affinity DataIC50: 20nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent