BDBM492370 US10975080, Example 68

SMILES COc1cccc(-c2n[nH]c3nc(N4CCC5(COC[C@H]5N)CC4)n(C)c(=O)c23)c1Cl

InChI Key InChIKey=WHWXESXLBKPIJE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492370   

LigandPNGBDBM492370(US10975080, Example 68)
Affinity DataIC50: 25nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent