BDBM492375 US10975080, Example 73

SMILES C[C@H]1C[C@@H](N)C2(C1)CCN(CC2)c1nc2[nH]nc(-c3ccnc(N(C)C)c3Cl)c2c(=O)n1C

InChI Key InChIKey=GXVMMWKICZYKFB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492375   

LigandPNGBDBM492375(US10975080, Example 73)
Affinity DataIC50: 28nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent