BDBM492381 US10975080, Example 79

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cc(Cl)ncc4Cl)c3c(=O)n2C)[C@@H]1N

InChI Key InChIKey=KACXEYFUINPBPC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492381   

LigandPNGBDBM492381(US10975080, Example 79)
Affinity DataIC50: 30nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent