BDBM492386 US10975080, Example 83

SMILES Cn1c(nc2[nH]nc(Sc3cccc(Cl)c3Cl)c2c1=O)N1CCC(C)(CN)CC1

InChI Key InChIKey=AIMSTVPTHUHVQI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492386   

LigandPNGBDBM492386(US10975080, Example 83)
Affinity DataIC50: 8nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent