BDBM492823 7-(((3-(difluoromethyl)- 1-(pyrazin-2-yl)-1H- pyrazol-4-yl)methyl) thio)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine::US10981879, Example 145::US10981879, Example 152

SMILES Nc1cc(SCc2cn(nc2C(F)F)-c2cnccn2)c2nn[nH]c2n1

InChI Key InChIKey=VFIABTOQYRWNMO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492823   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492823(US10981879, Example 152 | 7-(((3-(difluoromethyl)-...)
Affinity DataIC50: 30nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog #A12222) which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492823(US10981879, Example 152 | 7-(((3-(difluoromethyl)-...)
Affinity DataIC50: 80nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492823(US10981879, Example 152 | 7-(((3-(difluoromethyl)-...)
Affinity DataIC50: 600nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent