BDBM492844 7-(((5-chloro-3-methyl-1- phenyl-1H-pyrazol-4- yl)methyl)thio)-3H-[1,2,3] triazolo[4,5-b]pyridin-5- amine::US10981879, Example 79

SMILES Cc1nn(c(Cl)c1CSc1cc(N)nc2[nH]nnc12)-c1ccccc1

InChI Key InChIKey=KXTAHRPAFDJXNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 492844   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492844(US10981879, Example 79 | 7-(((5-chloro-3-methyl-1-...)
Affinity DataIC50: 7nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM492844(US10981879, Example 79 | 7-(((5-chloro-3-methyl-1-...)
Affinity DataIC50: 30nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog #A12222) which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent