BDBM494721 4-((2-(3- cyclopropylureido)ethyl)thio)-N-(4- fluorobicyclo[4.2.0]octa-1(6),2,4- trien-7-yl)-N''-hydroxy-1,2,5- oxadiazole-3-carboximidamide (peak 1)::US10988487, Example 117::US10988487, Example 118

SMILES O\N=C(/NC1Cc2ccc(F)cc12)c1nonc1SCCNC(=O)NC1CC1

InChI Key InChIKey=GGWGJTOQAKSBIS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 494721   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM494721(US10988487, Example 117 | 4-((2-(3- cyclopropylure...)
Affinity DataIC50: 42.9nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM494721(US10988487, Example 117 | 4-((2-(3- cyclopropylure...)
Affinity DataIC50: 1.10E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent