BDBM495105 US10995084, Ex. No. 4B-11

SMILES C[C@@H](NC(=O)c1cc(C)c(Oc2cc(C)n[nH]c2=O)c(F)c1)C(=O)N1[C@@H](CC[C@@H]1C1(COC1)C#N)c1cccc(Cl)c1

InChI Key InChIKey=LEYRYDKAZLRALV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 495105   

TargetCalcitonin gene-related peptide type 1 receptor(Human)
Kissei Pharmaceutical

US Patent
LigandPNGBDBM495105(US10995084, Ex. No. 4B-11)
Affinity DataIC50: 0.0200nMAssay Description:The binding affinity assay of compounds for human CGRP receptor was carried out by inhibition of radiolabeled ligand [125I]-CGRP binding in human neu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetCalcitonin gene-related peptide type 1 receptor(Human)
Kissei Pharmaceutical

US Patent
LigandPNGBDBM495105(US10995084, Ex. No. 4B-11)
Affinity DataKi:  0.0700nMAssay Description:The binding affinity assay of compounds for human CGRP receptor was carried out by inhibition of radiolabeled ligand [125I]-CGRP binding in human neu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent