BDBM495174 US10995089, Example 8::US11708364, Example 8

SMILES Cc1[nH]ncc1-c1cnc2[nH]cc(-c3ccn(Cc4cccc(Cl)c4)c(=O)c3)c2c1

InChI Key InChIKey=UTXCYONSWGIWHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 495174   

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495174(US10995089, Example 8 | US11708364, Example 8)
Affinity DataIC50: 10nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495174(US10995089, Example 8 | US11708364, Example 8)
Affinity DataIC50: 150nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent