BDBM495212 1-(3-Chloro-2-fluorobenzyl)-4-(5-(6-hydroxy-1,4-oxazepan-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2(1H)-one::US10995089, Example 120

SMILES OC1CN(CCCO1)c1cnc2[nH]cc(-c3ccn(Cc4cccc(Cl)c4F)c(=O)c3)c2c1

InChI Key InChIKey=LJYWOFUQEMQHCK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 495212   

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495212(US10995089, Example 120 | 1-(3-Chloro-2-fluorobenz...)
Affinity DataIC50: 150nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
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Date in BDB:
11/4/2021
Entry Details
US Patent