BDBM50000986 CHEMBL3235250

SMILES C[C@@H]1CC[C@@H](CCc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-n1nccn1

InChI Key InChIKey=WPHNPRFLOVEQIX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50000986   

TargetOrexin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000986(CHEMBL3235250)
Affinity DataKi:  26nMAssay Description:Binding affinity to human OX2 receptor in cell membrane by in vitro radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000986(CHEMBL3235250)
Affinity DataIC50: 145nMAssay Description:Antagonist activity at human OX2 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000986(CHEMBL3235250)
Affinity DataKi:  470nMAssay Description:Binding affinity to human OX1 receptor in cell membrane by in vitro radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000986(CHEMBL3235250)
Affinity DataIC50: 861nMAssay Description:Antagonist activity at human OX1 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed