BDBM50002245 4-[2-(1-Cyclopropylmethyl-piperidin-4-yl)-acetyl]-benzonitrile; compound with but-2-enedioic acid::CHEMBL130356::CHEMBL137776

SMILES O=C(CC1CCN(CC2CC2)CC1)c1ccc(cc1)C#N

InChI Key InChIKey=PEWGDLTXNPKKLN-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50002245   

TargetD(2) dopamine receptor(Mouse)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound was tested in vitro for its binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
New York University

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataKi:  10nMAssay Description:Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]- haloperidolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
New York University

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Mouse)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataKi: >1.00E+4nMAssay Description:The compound was tested in vitro for its binding affinity towards dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A/2B/2C(Mouse)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002245(CHEMBL130356 | CHEMBL137776 | 4-[2-(1-Cyclopropylm...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity for serotonin 5-hydroxytryptamine (5-HT) 2 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed