BDBM50005485 CHEMBL140836::CHEMBL3234256

SMILES CCN1C(=O)c2cccc3c(ccc1c23)S(=O)(=O)Nc1ccc(NC(C)=O)cc1

InChI Key InChIKey=HQYQJCSODDOMTE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50005485   

TargetNuclear receptor ROR-gamma(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005485(CHEMBL140836 | CHEMBL3234256)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005485(CHEMBL140836 | CHEMBL3234256)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005485(CHEMBL140836 | CHEMBL3234256)
Affinity DataIC50: 8.98E+4nMAssay Description:Antagonist activity at human His6-tagged RORgamma ligand binding domain (262 to 507 aa) assessed as inhibition of SRC1-4 co-activator peptide recruit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50005485(CHEMBL140836 | CHEMBL3234256)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21(DE3) cells using biotin-H4KAc4 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed