BDBM50007151 1-Aminomethyl-3-prop-2-ynyl-isochroman-5,6-diol::CHEMBL315849

SMILES NC[C@@H]1OC(CC#C)Cc2c(O)c(O)ccc12

InChI Key InChIKey=LWUHQVZWIKZZFZ-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007151   

TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007151(CHEMBL315849 | 1-Aminomethyl-3-prop-2-ynyl-isochro...)
Affinity DataEC50:  67nMAssay Description:Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007151(CHEMBL315849 | 1-Aminomethyl-3-prop-2-ynyl-isochro...)
Affinity DataEC50:  286nMAssay Description:Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007151(CHEMBL315849 | 1-Aminomethyl-3-prop-2-ynyl-isochro...)
Affinity DataKi:  407nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007151(CHEMBL315849 | 1-Aminomethyl-3-prop-2-ynyl-isochro...)
Affinity DataKi:  1.07E+3nMAssay Description:Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed