BDBM50007237 CHEMBL3238224

SMILES COc1cccc(c1)C1=N[C@@]2(CC[C@@H](CC2)C(C)(C)C)N([C@H](CCC(C)(C)C)c2ccc(cc2)C(=O)NCc2nn[nH]n2)C1=O

InChI Key InChIKey=QWLFOKHFURUCSA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007237   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007237(CHEMBL3238224)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007237(CHEMBL3238224)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007237(CHEMBL3238224)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GLP-1R expressed in CHO cells assessed as inhibition of GLP-1-stimulated cAMP production preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed