BDBM50007283 CHEMBL3238238

SMILES C[C@H](CC(O)=O)NC(=O)c1ccc(cc1)[C@@H](CCC(C)(C)C)N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=FKLMGSIRRLOLAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007283   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007283(CHEMBL3238238)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007283(CHEMBL3238238)
Affinity DataIC50: 6.10E+3nMAssay Description:Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007283(CHEMBL3238238)
Affinity DataIC50: 530nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007283(CHEMBL3238238)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GLP-1R expressed in CHO cells assessed as inhibition of GLP-1-stimulated cAMP production preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed