BDBM50007646 CHEMBL3233127

SMILES CC[C@@H](CN(c1ccccc1F)S(C)(=O)=O)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=TVELMQBTPDLJJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007646   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50007646(CHEMBL3233127)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50007646(CHEMBL3233127)
Affinity DataIC50: 4nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed