BDBM50008745 CHEMBL3236329

SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12

InChI Key InChIKey=IWCGRJRLSWGIIP-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50008745   

TargetSodium channel protein type 5 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 920nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.54E+3nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.77E+3nMAssay Description:Inhibition of human Nav1.8 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 5.66E+3nMAssay Description:Inhibition of human Nav1.8 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 6.34E+3nMAssay Description:Inhibition of human Nav1.8 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 8.54E+3nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of human Nav1.6 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed