BDBM50008990 1,2-Dihydro-indazol-3-one::1H-indazol-3-ol::CHEMBL276725

SMILES O=c1[nH][nH]c2ccccc12

InChI Key InChIKey=SWEICGMKXPNXNU-UHFFFAOYSA-N

Data  5 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50008990   

TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Uned

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of nNOS in LPS-stimulated Wistar rat striata assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of LTB4 production was measured in rat bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataIC50: 700nMAssay Description:In vitro inhibition of LTB4 (LT) production in dog bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibition of PGE-2 production was measured in rat bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataEC50: >7.45E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Pig)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50008990(CHEMBL276725 | 1H-indazol-3-ol | 1,2-Dihydro-indaz...)
Affinity DataKd:  4.43E+3nMAssay Description:Binding affinity to pig kidney DAAO by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed