BDBM50009211 CHEMBL3233178

SMILES CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(C)(=O)=O)C1)N1CC[C@H](NC(=O)c2cccc(c2)C(F)(F)F)C1=O

InChI Key InChIKey=KZYUPKXEHNEFIY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50009211   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009211(CHEMBL3233178)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]-labeled human MCP1 from CCR2 in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009211(CHEMBL3233178)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human ERG by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009211(CHEMBL3233178)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009211(CHEMBL3233178)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009211(CHEMBL3233178)
Affinity DataIC50: 1.64E+3nMAssay Description:Antagonist activity at CCR5 (unknown origin) expressed in human HT1080 cells assessed as blockade of MIP1beta-binding to receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed