BDBM50009331 CHEMBL3233843::US9346814, Cmpd No 24 Example 28

SMILES COc1ccc2nccc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)c2c1

InChI Key InChIKey=WVYNDXWJAOOXTA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009331   

TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 8.5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 1.90E+4nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 9(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 2.30E+4nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 8.30E+3nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009331(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed