BDBM50010593 1-(2-Chloro-5-isopropylidene-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine::CHEMBL328246

SMILES [#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6]-1=[#6]-c2cc(Cl)ccc2\[#6](=[#6](/[#6])-[#6])-c2ccccc-12

InChI Key InChIKey=SDYDLETYVYMXOI-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50010593   

TargetD(1A) dopamine receptor(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataIC50: 443nMAssay Description:Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity for Dopamine receptor D2 using [3H]spiperone in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataIC50: 1.75E+3nMAssay Description:Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]QNB as radioligand in rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  98nMAssay Description:Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  100nMAssay Description:Affinity was evaluated by inhibition of [3H]GR-65630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  230nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  370nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  690nMAssay Description:Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010593(CHEMBL328246 | 1-(2-Chloro-5-isopropylidene-5H-dib...)
Affinity DataKi:  930nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed