BDBM50011735 CHEMBL3262908::US20240336642, Example 2.3

SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1Cl

InChI Key InChIKey=DGGBONAICBOTBD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50011735   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50011735(CHEMBL3262908 | US20240336642, Example 2.3)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50011735(CHEMBL3262908 | US20240336642, Example 2.3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human 5-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50011735(CHEMBL3262908 | US20240336642, Example 2.3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50011735(CHEMBL3262908 | US20240336642, Example 2.3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human epithelial 15-lipoxygenase-2 using arachidonic acid as substrate by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12/ALOX15(Human)
The General Hospital

US Patent
LigandPNGBDBM50011735(CHEMBL3262908 | US20240336642, Example 2.3)
Affinity DataIC50: 670nMAssay Description:Assay: Compounds are dissolved in DMSO and diluted to 10 mM concentration in DMSO immediately before IC50 analysis. To determine inhibition of the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent