BDBM50013839 CHEMBL2030270

SMILES OC(=O)CSc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1O

InChI Key InChIKey=GVAXUAIZKLJWSB-UHFFFAOYSA-N

Data  6 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50013839   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataIC50: 7.12E+3nMAssay Description:Binding affinity to His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of MCL1-N-terminal b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKd:  3.66E+4nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataIC50: 4.61E+3nMAssay Description:Inhibition of recombinant Bfl-1 (1-152) (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibition of MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  6.14E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged A1-BFL-1 (1 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  3.75E+4nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  5.47E+4nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCL2 (1 to 202) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  9.90E+4nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCLX-L (1 to 209) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed