BDBM50014676 4-Hydroxy-6-[2-(2-methyl-5-phenyl-pyrrol-1-yl)-ethyl]-tetrahydro-pyran-2-one::CHEMBL106720

SMILES Cc1ccc(-c2ccccc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1

InChI Key InChIKey=GRYRYCIEQRBDRS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50014676   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014676(CHEMBL106720 | 4-Hydroxy-6-[2-(2-methyl-5-phenyl-p...)
Affinity DataIC50: 1.26E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014676(CHEMBL106720 | 4-Hydroxy-6-[2-(2-methyl-5-phenyl-p...)
Affinity DataIC50: 1.40E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014676(CHEMBL106720 | 4-Hydroxy-6-[2-(2-methyl-5-phenyl-p...)
Affinity DataIC50: 1.26E+4nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014676(CHEMBL106720 | 4-Hydroxy-6-[2-(2-methyl-5-phenyl-p...)
Affinity DataIC50: 1.30E+4nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed