BDBM50015703 4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzonitrile::CHEMBL62675

SMILES Nc1nc2ccc(CN(CC#C)c3ccc(cc3)C#N)cc2c(=O)[nH]1

InChI Key InChIKey=MZDJMEWMEZJEBS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015703   

TargetThymidylate synthase(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50015703(CHEMBL62675 | 4-[(2-Amino-4-oxo-3,4-dihydro-quinaz...)
Affinity DataIC50: 1.30E+3nMAssay Description:The compound was not tested for inhibition of L1210 Thymidylate synthase due to insolubilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50015703(CHEMBL62675 | 4-[(2-Amino-4-oxo-3,4-dihydro-quinaz...)
Affinity DataIC50: 6.66E+4nMAssay Description:Tested for 50% inhibition of WI-L2 Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed