BDBM50015704 6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-3H-quinazolin-4-one::CHEMBL433059

SMILES COc1cc(cc(OC)c1OC)N(CC#C)Cc1ccc2nc[nH]c(=O)c2c1

InChI Key InChIKey=LTWLIPOOXUTGEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015704   

TargetDihydrofolate reductase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50015704(CHEMBL433059 | 6-{[Prop-2-ynyl-(3,4,5-trimethoxy-p...)
Affinity DataIC50: 6.66E+4nMAssay Description:Tested for 50% inhibition of WI-L2 Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50015704(CHEMBL433059 | 6-{[Prop-2-ynyl-(3,4,5-trimethoxy-p...)
Affinity DataIC50: 9.60E+4nMAssay Description:The compound was not tested for inhibition of L1210 Thymidylate synthase due to insolubilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed