BDBM50016839 5-Methyl-6-[4-(4,5,6,7-tetrahydro-benzoimidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one::CHEMBL282765

SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1cnc2CCCCc12

InChI Key InChIKey=KDEKNYKHIZTSLE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50016839   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibitory concentration against cAMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibitory concentration against cGMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against cAMP PDE III enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 110nMAssay Description:Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50016839(CHEMBL282765 | 5-Methyl-6-[4-(4,5,6,7-tetrahydro-b...)
Affinity DataIC50: 501nMAssay Description:Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed