BDBM50017101 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoindol-3-one::CHEMBL35053

SMILES COc1cc2CC[C@H]3[C@@H](CNC3=O)c2cc1OC

InChI Key InChIKey=QWQNNBPCVVLDDY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50017101   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017101(CHEMBL35053 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017101(CHEMBL35053 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of phosphodiesterase from bovine aorta with 1 uM cGMP calcium (10 uM) and calmodulin (15 nM) (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017101(CHEMBL35053 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed