BDBM50017875 2-{4-[Ethyl-(4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid::CHEMBL170846

SMILES CCN(Cc1ccc2nc[nH]c(=O)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key InChIKey=BCAXXUAMVUQADK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50017875   

TargetDihydrofolate reductase(Rat)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50017875(CHEMBL170846 | 2-{4-[Ethyl-(4-oxo-3,4-dihydro-quin...)
Affinity DataKi:  58nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50017875(CHEMBL170846 | 2-{4-[Ethyl-(4-oxo-3,4-dihydro-quin...)
Affinity DataIC50: 520nMAssay Description:Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed