BDBM50018737 1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizine::1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine::CHEMBL345349

SMILES C1CCN2CCc3c([nH]c4ccccc34)C2C1

InChI Key InChIKey=OURDZMSSMGUMKR-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50018737   

TargetAlpha-1A adrenergic receptor(Bovine)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi:  38nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi:  38nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi:  60nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi:  60nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding to human D2L receptor expressed in HEK 293 cells by functional calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizi...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed