BDBM50019934 CHEMBL3287548

SMILES Fc1ccc2n(CCCOc3ccc(Cl)cc3)c3CCNCc3c2c1

InChI Key InChIKey=AYKQXOKTTGHBAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50019934   

TargetCytochrome P450 2C9(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50019934(CHEMBL3287548)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide conversion to 4-hydroxy tolbutamide preincubated for 10 mins followed by NADPH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50019934(CHEMBL3287548)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam conversion to 1'-hydroxy midazolam preincubated for 10 mins followed by NADPH ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50019934(CHEMBL3287548)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin conversion to 4'-hydroxy mephenytoin preincubated for 10 mins followed by N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50019934(CHEMBL3287548)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone conversion to 6-hydroxy testosterone preincubated for 10 mins followed by NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed